Prepare Fajita Seasoning by whisking together chili powder, cumin, smoked paprika, oregano, garlic powder, cayenne, salt, and pepper.

Sauté Shrimp & Vegetables: Heat olive oil in a large skillet, add shrimp and cook until pink. Stir in fajita seasoning, bell peppers, onion, and garlic.

Incorporate Crab: Fold in lump crabmeat, drizzle with lime juice, and mix in cilantro. Allow to cool.

Spread cream cheese across prepared tortillas, leaving a border around the edges.

Assemble Roll-Ups: Add cheddar cheese and cooled filling to tortillas, roll tightly and refrigerate for at least 2 hours.

Slice and Serve: Trim ends of roll-ups, slice into rounds, and arrange on a platter.